منابع مشابه
IL-21/IL-21R in Autoimmune Diseases
Interleukin-21 (IL-21), the member of the γ-chain-related cytokine family, and its receptor (IL-21R), has been evidenced involving in the immune response, resulting in the development of autoimmune diseases, infectious diseases and tumors. This short communication reviews an overall outline of its genetic variants and expression in autoimmune diseases. It focuses on a series of recent studies t...
متن کاملIL-37 restrains autoimmune diseases
Interleukin-37 (IL-37), a newly discovered member of the IL-1 family, has been identified as a natural inhibitor of immune responses [1]. The human IL-37 gene has been confirmed undergo alternative splicing and exists in five splice variants including IL-37a-e, but a mouse homologue has not been reported [2]. The most glaring is IL-37b that encodes the longest transcript variant includes exons ...
متن کاملIL-21R signaling is critical for induction of spontaneous experimental autoimmune encephalomyelitis.
IL-17-producing CD4+ T cells (Th17 cells) have well-described pathogenic roles in tissue inflammation and autoimmune diseases, such as experimental autoimmune encephalomyelitis (EAE); however, the involvement of IL-21 in these processes has remained controversial. While IL-21 is an essential autocrine amplification factor for differentiation of Th17 cells, the loss of IL-21 or IL-21 receptor (I...
متن کاملIFN- regulates IL-21 and IL-21R expression in human NK and T cells
Interleukin (IL)-21 is a T cell-derived cytokine that regulates innate and adaptive immune responses. IL-21 receptor (IL-21R), which is expressed in natural killer (NK) and T cells, is structurally homologous to IL-2R and IL-15R . These receptors also share a common cytokine receptor -chain with IL-4, IL-7, and IL-9. Macrophageor dendritic cell-derived interferon (IFN)/ is a key cytokine in reg...
متن کاملIL-10 Modulates Th17 Pathogenicity during Autoimmune Diseases
The immune system is essential for host defense against pathogen infections; however dysregulated immune response may lead to inflammatory or autoimmune diseases. Elevated activation of both innate immune cells and T cells such as Th17 cells are linked to many autoimmune diseases, including Multiple Sclerosis (MS), arthritis and inflammatory bowel disease (IBD). To keep immune homeostasis, the ...
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ژورنال
عنوان ژورنال: Journal of Clinical & Cellular Immunology
سال: 2016
ISSN: 2155-9899
DOI: 10.4172/2155-9899.1000412